期刊
EXPERT REVIEW OF PROTEOMICS
卷 4, 期 4, 页码 531-538出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.4.4.531
关键词
clinical proteomics; disease biomarker; human saliva proteome; saliva diagnostics
资金
- NIDCR NIH HHS [U01-DE016275, R03-DE017144] Funding Source: Medline
Human saliva is an attractive body fluid for disease diagnosis and prognosis because saliva testing is simple, safe, low-cost and noninvasive. Comprehensive analysis and identification of the proteomic content in human whole and ductal saliva will not only contribute to the understanding of oral health and disease pathogenesis, but also form a foundation for the discovery of saliva protein biomarkers for human disease detection. In this article, we have summarized the proteomic technologies for comprehensive identification of proteins in human whole and ductal saliva. We have also discussed potential quantitative proteomic approaches to the discovery of saliva protein biomarkers for human oral and systemic diseases. With the fast development of mass spectrometry and proteomic technologies, we are enthusiastic that saliva protein biomarkers will be developed for clinical diagnosis and prognosis of human diseases in the future.
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