期刊
DIABETOLOGIA
卷 50, 期 8, 页码 1698-1706出版社
SPRINGER
DOI: 10.1007/s00125-007-0705-1
关键词
fitness; hyperinsulinaemic-euglycaemic clamp; insulin resistance; insulin sensitivity (whole-body liver and fat); obesity (visceral, truncal and subcutaneous); PAEE; physical activity; physical activity energy expenditure
资金
- MRC [MC_U106179473] Funding Source: UKRI
- Medical Research Council [MC_U106179471, MC_U106179473] Funding Source: researchfish
- Medical Research Council [MC_U106179473, MC_U106179471] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Aims/hypothesis The relative contributions of fitness (maximal oxygen uptake), physical activity energy expenditure (PAEE) and fatness to whole-body, liver and fat insulin sensitivity is uncertain. The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat. Materials and methods We recruited 25 men (mean [SD] age 53 [6] years). Whole-body (M value) and liver (percentage suppression of endogenous glucose output) insulin sensitivity were estimated using a hyperinsulinaemic-euglycaemic clamp. Insulin sensitivity in fat (insulin sensitivity index for NEFA) was estimated during an OGTT. Total and truncal fat were measured by dual-energy X-ray absorptiometry, fitness by treadmill, and PAEE (n= 21) by 3 day heart rate monitoring and Baecke questionnaire. Results In univariate analyses, fatness was strongly associated with insulin sensitivity (whole-body, liver and fat). Fitness was associated with whole-body (r=0.53, p<0.007) and liver (0.42, p=0.04) insulin sensitivity, while PAEE was associated with liver insulin sensitivity (r=0.55, p=0.01). Regression models were established to describe associations between fatness, fitness and physical activity and measures of insulin sensitivity (whole-body, fat and liver) as outcomes. Only fatness was independently associated with whole-body insulin sensitivity (B coefficient -0.01, p=0.001). Fitness was not associated with any outcome. Only PAEE was independently associated with liver insulin sensitivity (B coefficient 13.5, p=0.02). Conclusions/interpretation Fatness explains most of the variance in whole-body insulin sensitivity. In contrast, PAEE explains most of the variance in liver insulin sensitivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据