期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 4, 页码 245-254出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.02.011
关键词
T cell activation; immunological synapse; supported bilayer; microfabrication; Nanotechnology
类别
T cell activation occurs when T cell receptors engage peptide-major histocompatibility complex (pMHC molecules displayed on the surface of antigen presenting cells (APCs). Clustering of TCRs and other receptors in physical patterns at the T-APC interface forms a structure known as an immunological synapse (IS). Studies of the IS are challenging due to the cell-cell contact context of the governing interactions. Model surfaces as synthetic APCs have thus been developed, where the type, quantity, and physical arrangement of ligands displayed to T cells are precisely controlled. These model systems have provided important insights into the structure and function of the IS. (c) 2007 Elsevier Ltd. All rights reserved.
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