期刊
BIOMATERIALS
卷 28, 期 23, 页码 3418-3426出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.04.017
关键词
post-operative adhesion; dextran; carboxymethyl dextran; carboxymethyl cellulose; In situ cross-linking hydrogel; rabbit sidewall defectcecum abrasion model
资金
- NIGMS NIH HHS [GM073626] Funding Source: Medline
Peritoneal adhesions are serious sequelae of surgery, and can cause significant morbidity and/or mortality due to pain, infertility, and bowel obstruction. We have designed and synthesized novel dextran (DX)-based injectable hydrogels for adhesion prevention, which are formed by mixing hydrazide-modified carboxymethyldextran (CMDX ADH) with aldehyde-modified DX (DX-CHO) or carboxymethylcellulose (CMC-CHO). At high polymer concentrations, hydrogels formed very quickly upon mixing, e.g. 5% CMDX ADH with 6% DX-CHO (= CMDX-DX; 1.8 s) and 5% CMDX-ADH with 6% CMC-CHO (= CMDX-CMC; 5.8 s). CMDX-DX shrank after gelling, while CMDX-CMC swelled. CMDX-ADH and CMC-CHO showed minimal to mild cytotoxicity to mesothelial cells and macrophages in vitro, while DX-CHO was very cytotoxic. However, all cross-linked gels had very mild cytotoxicity. When applied in a rabbit sidewall defect-bowel abrasion model of adhesion formation, CMDX-CMC greatly reduced the formation of adhesions while CMDX DX worsened them. (c) 2007 Elsevier Ltd. All rights reserved.
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