期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 405, 期 14, 页码 4799-4809出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-013-6874-5
关键词
LC-QTOF/MS; Metabolomics; Oat; Rye; Sugar beet; Dietary fiber
资金
- Nordic Centre of Excellence SYSDIET (Systems biology in controlled dietary interventions and cohort studies) [070014]
- OPUS (Optimal wellbeing, development and health for Danish children through a healthy New Nordic Diet)
- Nordea Foundation
- European Network of Excellence NuGO (The European Nutrigenomics Organization)
- EU Network of Excellence ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility)
- VINNOVA grant [2004-02285]
The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p < 0.01, q < 0.05). Two markers, 2,6-dihydroxybenzoic acid and 2-aminophenol sulfate, were increased after HF diet, along with a tentatively identified saponin derived from oat avenacosides. The untargeted metabolomics approach enabled the identification of two new markers of dietary fiber intake in human plasma. Further studies will be needed to verify if these markers could serve as compliance markers of fiber intake.
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