期刊
COMPUTATIONAL BIOLOGY AND CHEMISTRY
卷 31, 期 4, 页码 239-245出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.compbiolchem.2007.03.013
关键词
gene networks; inference; optimization; ordinary differential equations; noise; time-delay
Ordinary differential equations (ODE) have been widely used for modeling and analysis of dynamic gene networks in systems biology. In this paper, we propose an optimization method that can infer a gene regulatory network from time-series gene expression data. Specifically, the following four cases are considered: (1) reconstruction of a gene network from synthetic gene expression data with noise, (2) reconstruction of a Dene network from synthetic gene expression data with time-delay, (3) reconstruction of a gene network from synthetic gene expression data with noise and time-delay, and (4) reconstruction of a gene network from experimental time-series data in budding yeast cell cycle. (c) 2007 Elsevier Ltd. All rights reserved.
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