期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 4, 页码 236-244出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.04.003
关键词
Self-peptide-MHC; T-cell activation; pseudodimer; thymic selection
类别
资金
- NIAID NIH HHS [R01 AI022511-23, R01 AI022511] Funding Source: Medline
The mechanisms by which up T-cells are selected in the thymus and then recognize peptide MHC (pMHC) complexes in the periphery remain an enigma. Recent work particularly with respect to quantification of T-cell sensitivity and the role of self-ligands in T-cell activation has provided some important clues to the details of how TCR signaling might be initiated. Here, we highlight recent experimental data that provides insights into the initiation of T-cell activation and also discuss the main controversies and uncertainties in this area. (c) 2007 Elsevier Ltd. All rights reserved.
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