期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 15, 页码 4382-4386出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.01.115
关键词
chemokine receptor-2; CCR2 antagonist; chemotaxis; MCP-1; asthma; monocytes; quaternary ammonium salt
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. (c) 2007 Published by Elsevier Ltd.
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