期刊
TRENDS IN GENETICS
卷 23, 期 8, 页码 403-412出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.05.010
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资金
- Rural Development Administration (RDA), Republic of Korea [20070301034005] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- NIGMS NIH HHS [R01 GM064650-01] Funding Source: Medline
SWI/SNF chromatin remodeling ATPases control accessibility of the information stored in the genome. However, the in vivo role of these remodelers has remained poorly understood because null mutations in these result in embryonic lethality in most organisms. Recently, the study of conditional mutants in mammals and viable null mutants in plants, combined with genome wide expression studies in mammals, flies and plants, have implicated chromatin remodeling ATPases in the regulation of many developmental pathways in multicellular eukaryotes. In addition, these studies reveal striking functional specificity for chromatin remodeling in individual developmental processes.
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