期刊
HAEMATOLOGICA
卷 92, 期 8, 页码 1135-1138出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11133
关键词
multiple myeloma; bone marrow; plasma cells; free light chains; monoclonal immunoglobulins
类别
Increases in free light chain (FLC) production are associated with disease progression in multiple myeloma (MM). Using a double immunofluorescence staining method to produce a differential count of plasma cells in bone marrow, single populations were demonstrated, containing intact monoclonal immunoglobulins (M-Igs) in 74% and FLCs only in 8% of cases. However, 18% contained a mixture of both cell populations. Progression from cells making intact M-Ig to cells restricted to FLC only production occurred in individual cases during the course of their disease. The presence of FLC only cells was associated with shortened survival.
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