期刊
BIOLOGICAL CHEMISTRY
卷 388, 期 8, 页码 839-845出版社
WALTER DE GRUYTER & CO
DOI: 10.1515/BC.2007.100
关键词
2,4-dihydroxyquinoline; 4-hydroxy-2-alkylquinolines; mass spectrometry; natural product; Pseudomonas aeruginosa; PqsA
资金
- Canadian Institutes of Health Research [77642] Funding Source: Medline
- NIAID NIH HHS [R01AI063433, R01 AI063433] Funding Source: Medline
A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factors.
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