期刊
MOLECULES
卷 12, 期 8, 页码 1548-1557出版社
MDPI
DOI: 10.3390/12081548
关键词
Allanblackia monticola; Symphonia globulifera; phenolic compounds; leishmanicidal; anticholinesterase
In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity. Further bioguided phytochemical investigation led to the isolation of four benzophenones: guttiferone A (1), garcinol (2), cambogin (3) and guttiferone F (4), along with three xanthones: allanxanthone A (5), xanthone V-1 (6) and globulixanthone C (7) as active constituents. Compounds 1 and 6 were isolated from S. globulifera leaves, while compounds 2-5 were obtained from A. monticola fruits. Guttiferone A (1) and F (4) showed particulary strong leishmanicidal activity in vitro, with IC50 values (0.2 mu M and 0.16 mu M, respectively) comparable to that of the reference compound, miltefosine (0.46 mu M). Although the leishmanicidal activity is promising, the cytotoxicity profile of these compounds prevent at this state further in vivo biological evaluation. In addition, all the isolated compounds were tested in vitro for their anticholinesterase properties. The four benzophenones showed potent anticholinesterase properties towards acetylcholinesterase (ACNE) and butylcholinesterase (AChE). For ACNE, the IC50 value (0.66 mu M) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 mu M). Furthermore, guttiferone A (1) and guttiferone F (4) (IC50 = 2.77 and 3.50 mu M, respectively) were more active than galanthamine (ICSO = 8.5) against BChE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据