期刊
JOURNAL OF PROTEOME RESEARCH
卷 6, 期 8, 页码 3321-3328出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr070124b
关键词
polycystic ovary syndrome; 2DE; MALDI-TOF MS; complement proteins; haptoglobin
A variety of prefractionation methods (including a novel reversed-phase solid-phase-extraction (RP-SPE) combined with SDS-PAGE and proteomic based approaches (e.g., 2-dimensional gel electrophoresis (2DE) and MALDI-TOF mass spectrometry combined with Artificial Neural Network (ANN) bioinformatic tools) were used to investigate the protein/pepticle signatures in patients with Polycystic Ovary Syndrome (PCOS). Four potential PCOS biomarkers were identified (complement C4 alpha 3c and C4 gamma and haptoglobin alpha and beta chains).
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