期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 400, 期 9, 页码 2817-2825出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-011-4953-z
关键词
Optical imaging; Nonlinear interferometric vibrational imaging; Coherent anti-Stokes Raman scattering; Interferometry; Skin
资金
- National Institutes of Health (National Cancer Institute) [R21/R33 CA115536]
- Beckman Institute for Advanced Science and Technology
- Beckman Institute
The most prevalent molecular constituents of skin are spatially mapped by the use of nonlinear interferometric vibrational imaging, a coherent anti-Stokes Raman scattering (CARS)-based technique. Raman-like profiles over the range from 2,800 to 3,000 cm(-1) are acquired by means of completely suppressing the non-resonant background, allowing the generation of images based on the molecule-specific spectral profiles over the probed region with high spatial resolution. A simple algorithm that maps spectral content to color allows the visualization of histology in a manner analogous to that obtained with more conventional staining procedures (e.g., hematoxylin-eosin), but faster and with the benefit of having access to localized spectra, which could further enhance the potential for diagnosis of diseases, especially during the early stages of development.
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