期刊
SEMINARS IN CANCER BIOLOGY
卷 17, 期 4, 页码 299-308出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2007.06.008
关键词
CD8 T lymphocyte; anergy; tumor; tolerance
类别
资金
- NCI NIH HHS [R01 CA088956-05, R01 CA088956-04, R01 CA088956] Funding Source: Medline
- NIAID NIH HHS [P01 AI035296-14, P01 AI035296-150004, P01 AI35296, P01 AI035296-15, P01 AI035296] Funding Source: Medline
Naive CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-gamma production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion. (c) 2007 Elsevier Ltd. All rights reserved.
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