期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 401, 期 4, 页码 1377-1384出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-011-5159-0
关键词
Solid phase microextraction; Poly(3-alkylthiophenes); Linezolid; High-performance liquid chromatography
资金
- European Social Found
- Polish National Budget
- Kujawsko-Pomorskie Voivodship Budget
A novel sorbent in solid phase microextraction (SPME) method based on poly(3-alkylthiophenes) was used in the isolation of linezolid from human plasma samples following liquid chromatography determination. The effect of extraction time on the sorption capacity of the SPME process was studied and pointed at 10 min both for adsorption and desorption. Poly(3-methylthiophene) and poly(3-nonylthiophene) were applied for the extraction of linezolid from water solutions. In plasma samples, four coatings including polythiophene and poly(3-penthylthiophene) were investigated. With these measurements, correlation coefficients were calculated in the range from 0.9820 to 0.9995, and the relative standard deviations were below 15%. That allowed claiming that the synthesized and described materials can be successfully applied in the analysis of linezolid also from other matrices such as urine or blood.
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