期刊
FEBS JOURNAL
卷 274, 期 15, 页码 3756-3765出版社
WILEY
DOI: 10.1111/j.1742-4658.2007.05916.x
关键词
annyloid fibrils; branched-chain mechanism; in vitro conversion; polymerization kinetics; prion diseases; prion protein
资金
- NINDS NIH HHS [NS045585] Funding Source: Medline
The discovery of prion disease and the establishment of the protein only hypothesis of prion propagation raised substantial interest in the class of maladies referred to as conformational diseases. Although significant progress has been made in elucidating the mechanisms of polymerization for several amyloidogenic proteins and peptides linked to conformational disorders and solving their fibrillar 3D structures, studies of prion protein amyloid fibrils and their polymerization mechanism have proven to be very difficult. The present minireview introduces the mechanism of branched-chain reaction for describing the peculiar kinetics of prion polymerization and summarizes our current knowledge about the substructure of prion protein amyloid fibrils.
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