期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 399, 期 10, 页码 3555-3564出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-011-4730-z
关键词
Antidepressant; Desipramine; Trimipramine; Three-phase microextraction; Ion mobility spectrometry
资金
- Center of Excellence for Sensors and Green Chemistry, Isfahan University of Technology (IUT), Iran
A novel method based on three-phase hollow fiber microextraction technique (HF-LPME) coupled with electrospray ionization-ion mobility spectrometry (ESI-IMS) was developed for the simultaneous determination of two antidepressant drugs (trimipramine and desipramine) in urine and plasma samples. The effects of various parameters such as type of organic solvent, composition of donor and acceptor phase, stirring rate, salt addition, extraction time, and temperature were investigated. Under the optimized conditions, the relative standard deviation was in the range of 5-6%, and the method quantitation limit (MQL) of utilizing HF-LPME/ESI-IMS was 5 mu g/L for both drugs. The relative recoveries obtained by the proposed method from urine and plasma samples were in the range 94% to 97% for trimipramine and 92% to 96% for desipramine. Finally, the feasibility of the proposed method was successfully confirmed by extraction and determination of trace amounts of trimipramine and desipramine in biological samples without any significant matrix effect.
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