期刊
JOURNAL OF BIOSCIENCES
卷 32, 期 5, 页码 947-963出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-007-0095-z
关键词
aggregation reaction; codon usage; non-randomness; protein folding; protein secondary structure
类别
The relationship between the synonymous codon usage and different protein secondary structural classes were investigated using 401 Homo sapiens proteins extracted from Protein Data Bank (PDB). A simple Chi-square test was used to assess the significance of deviation of the observed and expected frequencies of 59 codons at the level of individual synonymous families in the four different protein secondary structural classes. It was observed that synonymous codon families show non-randomness in codon usage in four different secondary structural classes. However, when the genes were classified according to their GC 3 levels there was an increase in non-randonmess in high GC 3 group of genes. The non-randomness in codon usage was further tested among the same protein secondary structures belonging to four different protein folding classes of high GC 3 group of genes. The results show that in, each of the protein secondary structural unit there exist some synonymous family that shows class specific, codon-, usage pattern. Moreover, there is an increased non-random behaviour of synonymous codons in sheet structure of all secondary structural classes in high GC 3 group of genes. Biological implications of these results have been discussed.
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