期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 9, 期 8, 页码 1207-1219出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2007.1634
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资金
- NIGMS NIH HHS [P50 GM066309] Funding Source: Medline
- NINDS NIH HHS [R01-NS38632] Funding Source: Medline
Brain function depends exquisitely on oxygen for energy metabolism. Measurements of brain tissue oxygen tension, by a variety of quantitative and qualitative techniques, going back for >50 years, have led to a number of significant conclusions. These conclusions have important consequences for understanding brain physiology as it is now being explored by techniques such as blood-oxygen-level - dependent functional magnetic resonance imaging (BOLD fMRI) and near-infrared spectroscopy (NIRS). It has been known for some time that most of the measured oxygen tensions are less than venous pO(2) and are distributed in a spatially and temporally heterogeneous manner on a microregional scale. Although certain large- scale methods can provide reproducible average brain pO(2) measurements, no useful concept of a characteristic oxygen tension or meaningful average value for brain tissue oxygen can be known on a microregional level. Only an oxygen field exists with large local gradients due to local tissue respiration, and the most useful way to express this is with a pO(2) distribution curve or histogram. The neurons of the brain cortex normally exist in a low- oxygen environment and on activation are oxygenated by increases in local capillary blood flow that lead to increases in hemoglobin saturation and tissue oxygen.
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