期刊
SCHIZOPHRENIA RESEARCH
卷 94, 期 1-3, 页码 288-292出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2007.05.002
关键词
antipsychotics; hippocampus; longitudinal study; magnetic resonance imaging; olanzapine; schizophrenia
类别
Background: Previous studies have reported that hippocampal volumes correlate with symptom severity in schizophrenia. This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine. Methods: MRI scans were acquired from patients with chronic schizophrenia (n = 10) and healthy volunteers (n = 20). At baseline, patients were treated with typical antipsychotics for at least one year, then switched to olanzapine, and rescanned approximately one year later. Results: Olanzapine treatment resulted in no significant change in right or left hippocampal volume. Individual changes in right hippocampal volume correlated significantly with changes in symptoms. Conclusions: Hippocampal volume change may serve as a marker of symptom change in patients on olanzapine. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据