期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 86, 期 2, 页码 101-106出版社
SPRINGER JAPAN KK
DOI: 10.1532/IJH97.07087
关键词
human T-cell leukemia virus 1 (HTLV-1); adult T-cell leukemia (ATL); Tax; NF-kappa B; transformation
类别
资金
- Intramural NIH HHS Funding Source: Medline
Infection of T-cells by human T-cell leukemia virus type 1 (HTLV-1) causes a lymphoproliferative malignancy known as adult T-cell leukemia (ATL). ATL is characterized by abnormal lymphocytes, called flower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leukemogenesis; however, the mechanisms of HTLV-1 oncogenesis have not been clarified fully. In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据