期刊
BIOGERONTOLOGY
卷 8, 期 4, 页码 409-422出版社
SPRINGER
DOI: 10.1007/s10522-007-9084-8
关键词
cellular senescence; oxidative stress; ethanol; human fibroblasts; heme oxygenase; interleukin-11
Acute repeated exposures to subcytotoxic concentrations of tert-butylhydroperoxide and ethanol trigger premature senescence of human diploid fibroblasts. In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 inpremature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol. We tested whether interleukin-11 and heme oxygenase-1 could protect against tertbutyl-hydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction. No protective effect was found against the decrease of the proliferative potential, the increase of the proportion of senescence-associated 8-galactosidase positive cells and the increase of the mRNA levels of six senescence-associated genes.
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