期刊
INFECTION AND IMMUNITY
卷 75, 期 8, 页码 3859-3867出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00159-07
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资金
- NIAID NIH HHS [R01 AI 43559, R01 AI043559] Funding Source: Medline
Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.
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