期刊
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
卷 7, 期 4, 页码 324-330出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ACI.0b013e32825ea68a
关键词
antiretroviral therapy; drug hypersensitivity; HIV; major histocompatibility complex; pharmacogenetics
The increased predisposition of drug hypersensitivity disease in HIV will continue to provide a fertile ground for study of the diverse and complex processes that drive its pathophysiology. Our knowledge of drug hypersensitivity will also increase as the expanding armentarium of antiretroviral therapy is applied to more diverse populations in the developing world. The potential for widespread implementation of HLA-B*5701 screening for abacavir hypersensitivity will set an important precedent for bringing individualized medicine to the clinic and the use of genetic testing to improve drug safety.
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