期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 21, 期 6, 页码 727-735出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2007.05.005
关键词
neuroimmune; CNS; immune system; vagus; afferent nerves; blood-brain barrier; circumventricular organ
资金
- NIAID NIH HHS [R01 AI059089] Funding Source: Medline
- NIDA NIH HHS [R21 DA019396] Funding Source: Medline
- NINDS NIH HHS [R01 NS050547, R01 NS051334, R01 NS40098] Funding Source: Medline
Communication between the central nervous and immune systems lies at the heart of the neuroimmune axis. We trace here some of the major conceptual hurtles which were raised, first against the acceptance of a neuroimmune axis and later in understanding it. We review the major concepts formulated and established during the last two decades and focus on four pathways that have been proposed as important in communication: the neural route, circumventricular organs, blood-brain barrier transport of cytokines, and secretions from BBB cells. These and other pathways have established the existence of a neuroimmune axis, but raise new questions on how they act and interact with one another. Published by Elsevier Inc.
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