期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 398, 期 6, 页码 2535-2549出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-4018-8
关键词
Bioanalytical methods; Bioassays; Biosensors; Nucleic acids (DNA vertical bar RNA)
资金
- National Institutes of Health (NIH)
- NIH Roadmap for Medical Research [1-DP2-OD002190-01]
- Camille and Henry Dreyfus Foundation
- Eastman Chemical Company
In less than 20 years, our appreciation for micro-RNA molecules (miRNAs) has grown from an original, curious observation in worms to their current status as incredibly important global regulators of gene expression that play key roles in many transformative biological processes. As our understanding of these small, non-coding transcripts continues to evolve, new approaches for their analysis are emerging. In this critical review we describe recent improvements to classical methods of detection as well as innovative new technologies that are poised to help shape the future landscape of miRNA analysis.
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