期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 55, 期 8, 页码 1254-1257出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.1254
关键词
benzimidazole; zinc proline; water; recyclability
Zn-proline (5 mol%) performs as a novel water-soluble and recyclable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (42-92%) using water as solvent at ambient temperature.
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