期刊
GENOMICS
卷 90, 期 2, 页码 176-185出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2007.04.003
关键词
aryl hydrocarbon receptor; genetic regulatory networks; LINE-1; retrotransposon; siRNA knockdown
资金
- NIEHS NIH HHS [R01 ES004849, P30 ES014443-01A1, R01 ES004849-10, ES 04849, P30 ES014443] Funding Source: Medline
Computational approaches were used to define structural and functional determinants of a putative genetic regulatory network of murine LINE-1(long interspersed nuclear element-1), an active mammalian retrotransposon that uses RNA intermediates to populate new sites throughout the genome. Polymerase (RNA) II polypeptide E AI845735 and mouse DNA homologous to Drosophila per fragment M12039 were identified as primary attractors. siRNA knockdown of the aryl hydrocarbon receptor NM_013464 modulated gene expression within the network, including LINE-1, Sgpl1, Sdcbp, and Mgst1. Genes within the network did not exhibit physical proximity and instead were dispersed throughout the genome. The potential impact of individual members of the network on the global dynamical behavior of LINE-1 was examined from a theoretical and empirical framework. (c) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据