期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 397, 期 3, 页码 1203-1215出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-3674-z
关键词
Electrochemistry; Mass spectrometry; Biomimetic oxidation; DNA adduct; DNA oxidation; DNA damage
Oxidation is commonly involved in the alteration of nucleic acids giving rise to diverse effects including mutation, cell death, malignancy, and aging. We demonstrate that electrochemistry represents an efficient and fast method to mimic oxidative modification of nucleic acids occurring in biological systems. Oxidation reactions were performed in a thin-layer cell employing a conductive diamond electrode as the working electrode and were monitored with electrospray ionization-mass spectrometry. Mass voltammograms were acquired for guanosine, adenosine, cytidine, and uridine. The observed oxidation potentials increased in the order guanosine << adenosine
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据