期刊
PROTEOMICS
卷 7, 期 16, 页码 2933-2946出版社
WILEY
DOI: 10.1002/pmic.200700094
关键词
microevolution; Neisseria meningitidis; reference map; two-dimensional gel electrophoresis
Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. The availability of meningococcal genome sequences in combination with the rapid growth of proteomic techniques and other high-throughput methods, provided new approaches to the analysis of bacterial system biology. This review considers the meningococcal reference maps so far published as a starting point aimed to elucidate bacterial physiology and pathogenicity, paying particular attention to proteins with potential vaccine and diagnostic applications.
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