期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 15, 页码 4154-4157出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.05.063
关键词
praziquantel; praziquantel derivatives; schistosomiasis; anthelmintic
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis. (c) 2007 Elsevier Ltd. All rights reserved.
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