期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 15, 页码 4178-4182出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.05.048
关键词
benzothiazoles; semicarbazones; anticonvulsant activity; hydrophobic domain
A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character. (c) 2007 Elsevier Ltd. All rights reserved.
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