期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 394, 期 8, 页码 2183-2192出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-2893-7
关键词
Certified reference material; Purity; Semi-preparative HPLC
资金
- UK Department for Innovation
- Universities and Skills
A semi-preparative high-performance liquid chromatography process was evaluated as a tool to quantitatively determine the purity or percentage mass fraction content (% m/m) of organic compounds. The method is simple and does not require the identification and subsequent quantitation of organic-related structure impurities. A protocol was developed and tested on four reference materials certified for purity from 95% m/m to 99.3% m/m. Comparing the purity results of each certified reference material using the new approach with their respective certified values showed no significant analytical bias. Semi-preparative high-performance liquid chromatography has proved the potential to be a primary method directly traceable to mass with an uncertainty statement written down also in terms of mass with expanding uncertainty ranging from 0.8% to 1.3% m/m compared to 0.3 to 2.0% m/m for the certified purity values at the 95% confidence interval.
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