期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 396, 期 3, 页码 1025-1035出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-3250-6
关键词
Nanoparticles; Laser desorption/ionization; Mass spectrometry; Surface ligands
资金
- Office of Naval Research [N000140510501]
- NIH [GM077173]
- NSF [DMI-0531171]
Monolayer-protected gold nanoparticles (AuNPs) feature unique surface properties that enable numerous applications. Thus, there is a need for simple, rapid, and accurate methods to confirm the surface structures of these materials. Here, we describe how laser desorption/ionization mass spectrometry (LDI-MS) can be used to characterize AuNPs with neutral, positively, and negatively charged surface functional groups. LDI readily desorbs and ionizes the gold-bound ligands to produce both free thiols and disulfide ions in pure and complex samples. We also find that LDI-MS can provide a semi-quantitative measure of the ligand composition of mixed-monolayer AuNPs by monitoring mixed disulfide ions that are formed. Overall, the LDI-MS approach requires very little sample, provides an accurate measure of the surface ligands, and can be used to monitor AuNPs in complex mixtures.
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