期刊
JOURNAL OF ANTIBIOTICS
卷 60, 期 8, 页码 529-533出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2007.68
关键词
glycopeptide antibiotics; platelet aggregation; synthesis; antibacterial activity
The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.
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