期刊
CURRENT OPINION IN IMMUNOLOGY
卷 19, 期 4, 页码 476-483出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.05.009
关键词
-
类别
Increasingly, it is apparent that in order to understand the complexity of immunosurveillance at the cell-cell junction, quantitative analysis at the single cell level is necessary. The visualisation of the large-scale rearrangement of proteins characterising what is known as the immunological synapse (IS) was an important discovery shaping our understanding of the events occurring during immune recognition. The use of supported planar bilayers and geometrically designed substrates combined with advanced imaging techniques such as total internal reflection fluorescence (TIRF) and Forster resonance energy transfer (FRET) has provided insight into the spatio-temporal dynamics of receptor signalling and the role of receptor trafficking in regulating cell signalling. Theoretical modelling will play a key role in the integration of such quantitative data providing mechanistic insight into lymphocyte activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据