期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 391, 期 6, 页码 2329-2338出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2135-4
关键词
LC-MS/MS; drugs; oral fluid
An LC-MS/MS method using 0.5 ml of oral fluid was developed for the determination of morphine, codeine, 6-monoacetylmorphine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, benzoylecgonine, cocaine, delta-9-tetrahydrocannabinol, zolpidem, zopiclone, alprazolam, clonazepam, oxazepam, nordiazepam, lorazepam, flunitrazepam, diazepam, diphenhydramine and amitriptyline. The method was fully validated in terms of linearity (the method was linear between 1-5 mu g/L and 100-200 mu g/L) recoveries (7.5-82.6%), within-day and between-day precisions and accuracies (CV and MRE, both < 15%), limits of detection (0.5 mu g/L) and quantitation (the lowest point on the calibration curve), relative ion intensities, freeze-and-thaw stability and matrix effect. The method was applied to preserved oral fluid collected by a special commercial device, the StatSure Saliva Sampler (TM).
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