期刊
EXPERIMENTAL PARASITOLOGY
卷 116, 期 4, 页码 458-466出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2007.02.015
关键词
Nippostrongylus brasiliensis; nematode; Mycobacterium tuberculosis; galf, galactofuranose; galp, galactopyranose; Stat6, signal transducer and activator of transcription 6; intelectin; type 2 immunity; lung; small intestine
类别
资金
- NHLBI NIH HHS [P50 HL056385, HL56385, P50 HL056385-090001] Funding Source: Medline
- NIAID NIH HHS [R01 AI030663-18A1, AI30663, R01 AI030663] Funding Source: Medline
Elimination of the helminth parasite Nippostrongylus brasiliensis from infected mice is mediated by IL-4 or IL-13 and dependent on the IL-4R alpha chain and the transcription factor Stat6 in non-hematopoietic cells. However, it is not clear which Stat6-dependent effector molecules mediate worm expulsion. We identified intelectin-1 and -2 as Stat6-dependent genes that are induced during infection. Intelectins can bind galactofuranose, a sugar present only in microorganisms and might therefore serve as microbial pattern element. To analyze whether constitutive expression of intelectin-1 or -2 leads to accelerated pathogen clearance, transgenic mice were generated which express high levels of these genes selectively in the lung. Infection with N. brasiliensis or Mycobacterium tuberculosis did not result in accelerated pathogen clearance in transgenic as compared to wild-type mice. Further, no significant modulation of the immune response in lung or lymph nodes was observed. Thus, under these conditions, intelectins did not enhance pathogen clearance. (c) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据