期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 392, 期 6, 页码 1059-1073出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2248-9
关键词
Analytical methods; Cytochrome P450; Enzyme engineering; High-throughput screening; P450 substrates
资金
- Zentrum fur Angewandte Chemische Genomik
- European Union
- Ministry of Innovation and Research
Cytochrome P450s constitute a highly fascinating superfamily of enzymes which catalyze a broad range of reactions. They are essential for drug metabolism and promise industrial applications in biotechnology and biosensing. The constant search for cytochrome P450 enzymes with enhanced catalytic performances has generated a large body of research. This review will concentrate on two key aspects related to the identification and improvement of cytochrome P450 biocatalysts, namely the engineering and assaying of these enzymes. To this end, recent advances in cytochrome P450 development are reported and commonly used screening methods are surveyed.
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