期刊
CURRENT OPINION IN PHARMACOLOGY
卷 7, 期 4, 页码 412-417出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2007.06.001
关键词
-
The clinical success of TNF alpha blocking biologics in a growing number of immune-mediated pathologies, including rheumatoid arthritis, Crohn's disease, ankylosing spondylitis and psoriasis, confirms the importance of TNF alpha in driving chronic inflammation and represents an important step forward in the treatment of these conditions. TNFa blockade, however, is a treatment, rather than a cure, and is not effective in all patients or in all autoimmune diseases and further research is needed to get closer to a cure. Recently, the identification of a novel, IL-17 producing, T helper cell subset, that plays a dominant pathogenic role in animal models of autoimmunity, is a major advance on existing knowledge, although the role of these cells in human disease remains to be established. Cytokines driving angiogenesis are also important in disease chronicity and thus might be valid therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据