Effect of implanted Cu/low-density polyethylene nanocomposite on the mouse the morphology of endometrium in the mouse

Objective: To investigate the damage of endometrium caused by the implanted Cu/low-density polyethylene (LDPE) nanocomposite and the contraceptive effect of this novel copper-containing intrauterine device material. Design: Experimental animal study. Setting: TongJi Medical College of Huazhong University of Science and Technology. Patient(s): Sixty healthy female mice. Intervention(s): Twenty mice received no implants, 20 mice received the Cu/LDPE nanocomposite, and 20 mice received bulk copper. Main Outcome Measure(s): Morphologic features of the endometrium, contraceptive effect, and surface condition of the implanted implants. Result(s): The contraceptive effect of both the Cu/LDPE nanocomposite and bulk copper is 100%, the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper, and the surface of the implanted Cu/LDPE nanocomposite is much smoother and much softer than that of the implanted bulk copper. Condusion(s): The contraceptive effect of the Cu/LDPE nanocomposite is comparable with that of bulk copper, and the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper. The endometrium injury is related to the surface condition of the implanted intrauterine device material. (Fertil Steril((R)) 2007;88:472-8. (c) 2007 by American Society for Reproductive Medicine.).