期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 4, 页码 216-224出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.02.012
关键词
T cell receptor; peptide; MHC; polyspecificity; recognition
类别
资金
- NIAID NIH HHS [R01 AI033608, R13 AI068354-01, P01 AI045757-09, P01 AI045757, R01 AI064177, R13 AI068354, R01 AI064177-03] Funding Source: Medline
- NIGMS NIH HHS [R01 GM044809] Funding Source: Medline
A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes. (c) 2007 Elsevier Ltd. All rights reserved.
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