期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 15, 页码 4323-4327出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.05.025
关键词
prostaglandin
Analogs of PGE(2) with introduction of diene groups at the co-side chain have been synthesized and evaluated for their binding affinity for EP2 and EP4 receptors. An optimized analog (compound 9b) showed high potency and selectivity for the EP4 receptor over other known receptors. (c) 2007 Elsevier Ltd. All rights reserved.
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