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GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons

期刊

CURRENT OPINION IN LIPIDOLOGY
卷 18, 期 4, 页码 389-396

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e3281527914

关键词

chylomicronemia; glycosylphosphatidylinositol-anchored proteins; hypertriglyceridemia; lipoprotein lipase

资金

  1. NHLBI NIH HHS [P01 HL090553-04, P01 HL090553-02S2, R01 HL087228-03, R01 HL094732, R01 HL094732-03, R01 HL087228, HL66621, R01 HL087228-01, R01 HL094732-01S1, U01 HL066600, R01 HL094732-02, R01 HL087228-05, R01 HL094732-01, P01 HL090553, HL66600, R01 HL087228-04, P01 HL090553-03, U01 HL066621] Funding Source: Medline

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The chylomicronemia in Gpihbp1-deficient mice, the fact that GPIHBP1 is located within the lumen of capillaries, and the fact that GPIHBP1 binds lipoprotein lipase and chylomicrons suggest that GPIHBP1 is a key platform for the lipolytic processing of triglyceride-rich lipoproteins.

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