期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 188, 期 1-2, 页码 56-63出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.05.007
关键词
lymphocyte; neuron; mu-opioid receptor; interleukin-4; mitogen activated protein kinase; tumor necrosis factor
Morphine modulates neuronal and immune cell functions via [mu-opioid receptors. In primary and Jurkat T cells, and Raji B cells P-opioid receptor transcripts were detected only after stimulation of the cells with IL-4 or TNF-alpha. Moreover, the amount of the induced It-opioid receptor mRNA in the immune cells was 15 to 200 times less than those in primary cortical and SH SY5Y neuronal cells. Nevertheless, P-opioid receptor mRNA in immune cells is processed to functional receptors, as demonstrated by morphine-mediated phosphorylation of mitogen activated protein kinase, morphine-mediated up-regulation of IL-4 mRNA and coupling to adenylyl cyclase in Jurkat cells. (c) 2007 Elsevier B.V All rights reserved.
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