期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 349, 期 11-12, 页码 1882-1886出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700158
关键词
asymmetric catalysis; asymmetric synthesis; Michael addition; organic catalysis
An organocatalytic, enantioselective domino Michael-aldol reaction of 2-mercaptobenzaldehydes with maleimides has been developed. The process, catalyzed by a bifunctional chiral amine thiourea via a hydrogen-bonding mediated activation mechanism using as low as 1 mol% catalyst loading, affords versatile succinimide-containing benzothiopyrans with the generation of 3 stereogenic centers in one single operation.
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