期刊
CURRENT OPINION IN MICROBIOLOGY
卷 10, 期 4, 页码 320-325出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2007.05.014
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- NHLBI NIH HHS [R01 HL088905, R01HL088905, R01 HL088905-05] Funding Source: Medline
- NIAID NIH HHS [R01AI051209, R01 AI050184-05, R01 AI051209-03, R01 AI050184, R01 AI051209] Funding Source: Medline
Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses during growth in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutrient deprivation. There have been many genes implicated in resistance to individual stresses. Notably, the catalases do not have the expected role in resistance to external oxidative stress, but specific peroxidases appear to be critical for resistance to both oxidative and nitrosative stresses. Signal transduction through the HOG1 and calcineurin/ calmodulin pathways has been implicated in the stress response. Microarray and proteomic analyses have indicated that the common responses to stress are induction of metabolic and oxidative stress genes, and repression of genes encoding translational machinery.
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