期刊
NEURON
卷 55, 期 3, 页码 435-447出版社
CELL PRESS
DOI: 10.1016/j.neuron.2007.06.038
关键词
-
资金
- NHLBI NIH HHS [R01 HL059873-04, R01 HL059873, R01 HL059873-08, R01 HL059873-03, R01 HL059873-09A2, R01 HL059873-06, R01 HL059873-05, R01 HL59873, R01 HL059873-07] Funding Source: Medline
- NINDS NIH HHS [P30 NS047243-02, P30 NS047243-019001, P30 NS047243-01, P30 NS047243-03, P30 NS047243, P30 NS047243-04] Funding Source: Medline
Previous studies suggest that glia may be required for normal circadian behavior, but glial factors required for rhythmicity have not been identified in any system. We show here that a circadian rhythm in Drosophila Ebony (N-beta-alanylbiogenic amine synthetase) abundance can be visualized in adult glia and that glial expression of Ebony rescues the altered circadian behavior of ebony mutants. We demonstrate that molecular oscillator function and clock neuron output are normal in ebony mutants, verifying a role for Ebony downstream of the clock. Surprisingly, the ebony oscillation persists in flies lacking PDF neuropeptide, indicating it is regulated by an autonomous glial oscillator or another neuronal factor. The proximity of Ebony-containing glia. to aminergic neurons and genetic interaction results suggest a function in dopaminergic signaling. We thus suggest a model for ebony function wherein Ebony glia participate in the clock control of dopaminergic function and the orchestration of circadian activity rhythms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据