期刊
ANALYTICA CHIMICA ACTA
卷 831, 期 -, 页码 60-64出版社
ELSEVIER
DOI: 10.1016/j.aca.2014.05.001
关键词
Colorimetric detection; DNAzyme; Gold nanoparticle; Graphene oxide; Lead ion
资金
- National Science Fund for Distinguished Young Scholars [20925520]
- National Natural Science Foundation of China [21235003]
In this paper, we report a novel colorimetric strategy for the detection of small molecules by using Pb2+ ion as an example. In this strategy, DNAzyme duplex modified gold nanoparticles (GNPs) are designed to be unable to interact with graphene oxide (GO). However, in the presence of Pb2+, the substrate strand of the DNAzyme is cleaved at its cleavage site, resulting in the disassembly of the DNAzyme duplex modified GNPs into three parts, i.e., the 3'-and 5'-fragments of substrate strand and the DNAzyme strand modified GNPs. By taking advantage of the efficient cross-linking effect of ssDNA-GNPs to GO, colorimetric sensor for the detection of the metal ion can be fabricated with a detection limit of 100 pM, which is much lower than the previous reports. This colorimetric method has also been used for the determination of Pb2+ in the tap water of the local city and the water from a reservoir with satisfactory results, so it may have potential applications in the future. (C) 2014 Elsevier B. V. All rights reserved.
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